. 2016 Apr 15;33(8):1967–1978. doi: 10.1093/molbev/msw072

Table 1.

Biological Processes and Genes Associated with Age in Gray Wolves.

Enriched GO Term^a	GO P Value	Gene Symbol	Ensembl Gene ID	Annual FD	Q Value^b
Regulation of metabolic process	2.25E-5	ETS1	ENSCAFG00000010304	0.900	<0.001
Regulation of metabolic process		CDK4	ENSCAFG00000000280	0.910	0.137
RNA metabolic process	1.91E-5	DKC1	ENSCAFG00000019620	0.948	0.175
RNA metabolic process		NOP56	ENSCAFG00000006651	0.958	0.198
Chromatin modification	2.97E-3	SIRT6	ENSCAFG00000019123	0.896	0.200
Chromatin modification		HIRA	ENSCAFG00000014619	0.974	0.137
Immune response	6.28E-6	DLA-DQA1	ENSCAFG00000000812	0.945	0.137
		DLA-DRA	ENSCAFG00000000803	0.950	0.146
		DLA-88	ENSCAFG00000000487	0.945	0.180
		DLA-DOB	ENSCAFG00000000819	0.883	0.175
Lymphocyte activation	1.55E-9	IL7	ENSCAFG00000008373	0.907	0.180
		IL27RA	ENSCAFG00000016504	0.919	0.146
		CD5	ENSCAFG00000016332	0.938	0.157
		CXCR5	ENSCAFG00000012439	0.898	0.175
Lipid metabolic process	1.17E-2	LEP	ENSCAFG00000001672	1.078	0.151
		LIAS	ENSCAFG00000015991	1.035	0.183
		LIPH	ENSCAFG00000013246	1.113	0.184

^aA comprehensive gene list and full GO results are presented in supplementary tables S2–S4, Supplementary Material online.

^b Q values of genes significantly associated with age after controlling for relatedness, social rank, mange presence, and sex using linear mixed effects models.