Table 1.

Principal agents being tested for possible disease-modifying therapies for Alzheimer’s disease.

Beta-amyloid-related strategies

Vaccination/immunization

Beta-secretase inhibitors

Gamma-secretase modulators or inhibitors

Alpha-secretase enhancers

Fibrillization inhibitors

Statins

PPAR-gamma agonists and related agents

Zinc and copper chelators

Neuroprotective strategies

Nerve growth factor-related agents

Antioxidants

Anti-inflammatory agents

NMDA-receptor antagonists

AMPA-receptor antagonists

Anti-apoptic agents/caspase inhibitors/cell cycle inhibitors

Tan-related therapeutics

Specific estrogen receptor modulators

Monoamine oxidase B inhibitors

Nicotinic agonists

Muscarinic agonists

Calcium channel blocking agents

Folic acid and related agents