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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Cytokine. 2016 Oct 27;98:33–41. doi: 10.1016/j.cyto.2016.10.012

Figure 1. Receptors involved in hematological malignancies and their associated Janus kinases.

Figure 1

(A) Erythropoietin receptor on red blood cell progenitors; (B) IL-7 receptor on T cells; (C) TSLP receptor on B cells; (D) IL-13 receptor on B cells. Binding of the cytokine induces dimerization of receptor subunits, auto- and trans-phosphorylation of the JAKs and recruitment, phosphorylation, and activation of STATs. Aberrant expression or activation of various subunits of the receptor complexes leads to constitutive activation of the pathways, resulting in malignancy.