Table 2. Medians and statistical analysis of the cytokines baseline levels.
| Dunn's multiple comparisons test | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Non TB | LTBI | Active TB | Normal range | Kruskal-Wallis test | NIL NEG vs. NIL LTBI | NIL NEG vs. NIL ACTIVE TB | NIL LTBI vs. NIL ACTIVE TB | ||
| Analyte | % of patients upper normal range | % of patients upper normal range | % of patients upper normal range | p value | p value | p value | p value | ||
| Basic FGF | 90% | 78% | 96% | 1.30–55.00 | 0,0528 | ns | >0,9999 | 0,1022 | 0,1197 |
| Eotaxin | 85% | 88% | 93% | 1.20–39.00 | 0,5465 | ns | >0,9999 | >0,9999 | 0,851 |
| G-CSF | 100% | 97% | 100% | <1.50 | 0,1157 | ns | 0,7201 | 0,1141 | 0,8366 |
| GM-CSF | 45% | 50% | 48% | 0.80–122.00 | 0,8664 | ns | >0,9999 | >0,9999 | >0,9999 |
| IFN-γ | 40% | 75% | 70% | 0.60–124.00 | 0,0537 | ns | 0,0519 | 0,2127 | >0,9999 |
| IL-1β | 100% | 97% | 100% | 0.02–0.70 | 0,0051 | ** | 0,0179 | 0,0077 | >0,9999 |
| IL-1ra | 20% | 16% | 15% | 0.20–665.00 | 0,0562 | ns | 0,1565 | 0,0629 | >0,9999 |
| IL-2 | 10% | 6% | 4% | 0.03–90.00 | 0,0341 | * | 0,1194 | 0,036 | >0,9999 |
| IL-4 | 85% | 84% | 93% | 0.01–3.00 | 0,218 | ns | 0,253 | 0,6588 | >0,9999 |
| IL-5 | 5% | 6% | 0% | 0.01–7.00 | 0,7723 | ns | >0,9999 | >0,9999 | >0,9999 |
| IL-6 | 100% | 97% | 100% | 0.02–9.00 | 0,0934 | ns | 0,0917 | 0,4415 | >0,9999 |
| IL-7 | 30% | 38% | 26% | 0.01–14.00 | 0,4545 | ns | 0,629 | >0,9999 | >0,9999 |
| IL-8 | 100% | 97% | 93% | 0.08–116.00 | 0,0161 | * | 0,5306 | 0,0132 | 0,2461 |
| IL-9 | 20% | 6% | 22% | 0.38–500.00 | 0,1278 | ns | 0,6297 | 0,1279 | >0,9999 |
| IL-10 | 100% | 97% | 100% | 0.10–2.00 | 0,7698 | ns | >0,9999 | >0,9999 | >0,9999 |
| IL-12(p70) | 100% | 91% | 96% | 0.10–6.00 | 0,0062 | ** | 0,0167 | 0,01 | >0,9999 |
| IL-13 | 20% | 28% | 35% | 0.01–9.00 | 0,0867 | ns | 0,2386 | 0,0994 | >0,9999 |
| IL-15 | 55% | 69% | 56% | 0.06–5.00 | 0,2735 | ns | 0,3651 | >0,9999 | 0,8823 |
| IL-17 | 95% | 100% | 100% | 0.22–31.00 | 0,0779 | ns | >0,9999 | 0,0819 | 0,4117 |
| IP-10 | 80% | 81% | 89% | 5.90–637.00 | 0,2025 | ns | 0,6522 | >0,9999 | 0,277 |
| MCP-1 (MCAF) | 95% | 97% | 100% | 2.00–48.00 | 0,0102 | * | 0,1554 | 0,0075 | 0,5804 |
| MIP-1α | 95% | 97% | 96% | 0.01–2.00 | 0,1592 | ns | 0,2462 | 0,2905 | >0,9999 |
| MIP-1β | 85% | 69% | 85% | 1.70–47.00 | 0,4969 | ns | 0,7958 | >0,9999 | >0,9999 |
| PDGF–BB | 0% | 0% | 7% | 6.00–3,667.00 | 0,0143 | * | 0,5805 | 0,0123 | 0,201 |
| RANTES | 85% | 84% | 81% | 100,00–2.282,00 | 0,3143 | ns | 0,7307 | 0,4309 | >0,9999 |
| TNF-α | 55% | 81% | 89% | 0.10–98.00 | 0,051 | ns | 0,0652 | 0,1298 | >0,9999 |
| VEGF | 100% | 100% | 100% | 0.01–9.00 | 0,0298 | * | 0,039 | 0,0814 | >0,9999 |
| CTACK | 60% | 76% | 100% | 1.00–1,086.00 | 0,3238 | ns | 0,5438 | 0,5198 | >0,9999 |
| GRO-a | 80% | 94% | 100% | 9.00–365.00 | 0,6316 | ns | >0,9999 | >0,9999 | > 0,9999 |
| HGF | 30% | 24% | 11% | 63.00–1,868.00 | 0,5387 | ns | >0,9999 | 0,8739 | >0,9999 |
| IFN-α2 | 60% | 59% | 44% | 3.30–63.00 | 0,6583 | ns | >0,9999 | >0,9999 | >0,9999 |
| IL-1a | 59% | 100% | 100% | 0.40–1.40 | 0,4344 | ns | >0,9999 | 0,8889 | 0,7695 |
| IL-2Ra | 20% | 12% | 11% | 28.00–594.00 | 0,7087 | ns | >0,9999 | >0,9999 | >0,9999 |
| IL-3 | 100% | 94% | 100% | 13.00–170.00 | 0,8275 | ns | >0,9999 | >0,9999 | >0,9999 |
| IL-12(p40) | 80% | 71% | 89% | 36.00–646.00 | 0,5405 | ns | >0,9999 | >0,9999 | 0,8275 |
| IL-16 | 0% | 0% | 0% | 10.00–1,270.00 | 0,131 | ns | 0,1413 | 0,377 | >0,9999 |
| IL-18 | 10% | 6% | 6% | 9.00–812.00 | 0,2328 | ns | 0,2645 | 0,7535 | >0,9999 |
| LIF | 80% | 82% | 94% | 4.00–55.00 | 0,048 | * | >0,9999 | 0,0751 | 0,1916 |
| MCP-3 | 70% | 82% | 94% | 1.00–78.00 | 0,2451 | ns | >0,9999 | 0,3016 | 0,9322 |
| M-CSF | 40% | 53% | 28% | 6.00–208.00 | 0,6022 | ns | >0,9999 | >0,9999 | 0,9684 |
| MIF | 80% | 65% | 94% | 6.00–2,003.00 | 0,263 | ns | >0,9999 | 0,3635 | 0,7695 |
| MIG | 60% | 18% | 50% | 86.00–7,911.00 | 0,1655 | ns | 0,174 | 0,7619 | >0,9999 |
| b-NGF | 100% | 82% | 94% | <1.10 | 0,4464 | ns | 0,7495 | >0,9999 | 0,9538 |
| SCF | 0% | 0% | 0% | 16.00–837.00 | 0,7475 | ns | >0,9999 | >0,9999 | >0,9999 |
| SCGF-b | 0% | 0% | 0% | 6,054.00–130,932.00 | 0,1127 | ns | 0,2636 | >0,9999 | 0,2024 |
| SDF-1a | 100% | 94% | 100% | 8.00–92.00 | 0,9409 | ns | >0,9999 | >0,9999 | >0,9999 |
| TNF-β | 30% | 47% | 33% | 0.71–13.00 | 0,8992 | ns | >0,9999 | >0,9999 | >0,9999 |
| TRAIL | 0% | 0% | 6% | 8.00–272.00 | 0,6917 | ns | >0,9999 | >0,9999 | >0,9999 |
Median baseline levels of cytokines analyzed in the three groups, Kruskal-Wallis test with Dunn’s correction.
* p<0.05
**p<0.01.
The bold cytokines show higher concentrations than the normal range.
Fr. is the frequency of subjects with a higher cytokine concentration than the normal range.