Table 6. ROC curves features of the 14 markers increased in active TB.
ROC curve of non TB vs Active TB (Ag-Nil) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Area under the ROC curve | Std. Error | 95% confidence interval | p value | cutoff | Sensitivity% | 95% CI | Specificity% | 95% CI | Likelihood ratio | |
IL2 | 0.7778 | 0.09485 | 0.5918 to 0.9637 | 0.02539 | > 42.13 | 81.48 | 61.92% to 93.70% | 95 | 75.13% to 99.87% | 16.3 |
IP10 | 0.7942 | 0.07397 | 0.6492 to 0.9393 | 0.000704 | > 6557 | 80.77 | 60.65% to 93.45% | 85 | 62.11% to 96.79% | 5.385 |
IFN-γ | 0.8269 | 0.06213 | 0.7051 to 0.9487 | 0.000148 | > 57.38 | 70.37 | 49.82% to 86.25% | 90 | 68.30% to 98.77% | 7.037 |
MIG | 0.8944 | 0.07156 | 0.7542 to 1.035 | 0.000669 | > 6.456 | 94.44 | 72.71% to 99.86% | 90 | 55.50% to 99.75% | 9.444 |
SCF | 0.9353 | 0.05365 | 0.8301 to 1.040 | 0.000205 | > 39.37 | 94.12 | 71.31% to 99.85% | 90 | 55.50% to 99.75% | 9.412 |
b-NGF | 0.8765 | 0.06869 | 0.7418 to 1.011 | 0.00132 | > 1.965 | 70.59 | 44.04% to 89.69% | 90 | 55.50% to 99.75% | 7.059 |
IL12-p40 | 0.8944 | 0.06315 | 0.7706 to 1.018 | 0.000669 | > 86.37 | 83.33 | 58.58% to 96.42% | 90 | 55.50% to 99.75% | 8.333 |
TRAIL | 0.9028 | 0.06148 | 0.7823 to 1.023 | 0.000513 | > 34.01 | 83.33 | 58.58% to 96.42% | 90 | 55.50% to 99.75% | 8.333 |
IL2 Ra | 0.8333 | 0.08273 | 0.6711 to 0.9955 | 0.005499 | > 21.69 | 55.56 | 30.76% to 78.47% | 88.89 | 51.75% to 99.72% | 5 |
MIF | 0.8706 | 0.06827 | 0.7367 to 1.004 | 0.00157 | < 110.1 | 76.47 | 50.10% to 93.19% | 90 | 55.50% to 99.75% | 7.647 |
TNF-β | 0.8667 | 0.06776 | 0.7338 to 0.9995 | 0.001563 | > 5.405 | 72.22 | 46.52% to 90.31% | 90 | 55.50% to 99.75% | 7.222 |
IL3 | 0.8 | 0.08311 | 0.6371 to 0.9629 | 0.009651 | > 155.0 | 66.67 | 40.99% to 86.66% | 90 | 55.50% to 99.75% | 6.667 |
IFN-α | 0.8667 | 0.0723 | 0.7249 to 1.008 | 0.001563 | > 13.35 | 83.33 | 58.58% to 96.42% | 90 | 55.50% to 99.75% | 8.333 |
LIF | 0.7778 | 0.08809 | 0.6051 to 0.9505 | 0.01655 | > 25.70 | 66.67 | 40.99% to 86.66% | 90 | 55.50% to 99.75% | 6.667 |