Table 2. Regression analysis of complication rate.
| Univariable analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|
| Factors | P value | HR | 95% CI | P value | HR | 95% CI |
| Patient characteristics | ||||||
| Female sex | 0.244 | 0.628 | 0.287–1.373 | |||
| Age > 60 years | 0.068 | 2.095 | 0.946–4.639 | 0.022 | 3.118 | 1.176–8.262 |
| BMI > 30 | 0.638 | 0.977 | 0.885–1.078 | |||
| Current smoking | 0.741 | 0.848 | 0.320–2.248 | |||
| Comorbidity | ||||||
| ASA score ≥ 3 | 0.260 | 2.020 | 0.595–6.861 | |||
| Cardiovascular medication | 0.224 | 1.635 | 0.741–3.607 | |||
| Diabetic medication | 0.979 | 1.025 | 0.164–6.407 | |||
| Syst. corticosteroid medication | 0.248 | 3.621 | 0.408–32.140 | |||
| Obstructive lung disease | 0.070 | 7.000 | 0.853–57.448 | 0.057 | 8.231 | 0.936–73.999 |
| Tumor characteristics | ||||||
| High CRS (3–5) [21] | 0.728 | 1.148 | 0.527–2.502 | |||
| Bilobar disease | 0.615 | 1.238 | 0.539–2.845 | |||
| Treatment | ||||||
| Neoadjuvant chemo | 0.405 | 0.704 | 0.308–1.608 | |||
| > 1 liver segment surgery | 0.146 | 1.075 | 0.445–2.598 | 0.079 | 2.422 | 0.902–6.502 |
| Major liver surgery | 0.872 | 1.808 | 0.814–4.018 | |||
| RFA performed | 0.979 | 1.011 | 0.463–2.206 | |||
| APR performed | 0.010 | 4.535 | 1.425–14.433 | 0.027 | 4.382 | 1.180–16.277 |
| Operation > 8 hours | 0.008 | 2.986 | 1.333–6.688 | 0.489 | 1.417 | 0.528–3.802 |
| Blood loss > 500ml | 0.167 | 1.768 | 0.788–3.968 | 0.315 | 1.671 | 0.613–4.554 |
A binary logistic regression analysis was performed with complication rate as the dependent variable (n = 106). Variables with a p-value < 0.17 were entered in the multivariable analysis.
RFA = radiofrequency ablation, APR = abdominoperineal resection, CRS = clinical risk score, BMI = body mass index, ASA-score = American Society of Anaesthesiologists physical status classification system.