Fig. 3.
(A) Simulated APs of hPSC-CMs with different upstroke durations (0.2–4 ms) and (B) the corresponding SPICE derived FPs (Cje = 50 pF; Rj = 100 MOhm). Slope upstroke of the different APs against the slope upstroke (C) and slope decay (D) of the corresponding SPICE derived FPs. (E) FPs measured from hPSC-CMs, treated with different concentrations of tetrodotoxine (TTX). Slopes quantified from the upstroke (initiation to 0′) (F) and from the decay (0′ to 1′) (G).