Table 2. Radiological features are associated with unique pathway alterations in breast invasive carcinoma.

Lists of molecules (proteins and post-translational modifications) were analyzed in IPA. Top pathways for each feature are shown with the associated –log (p-value) computed by IPA demonstrating the strength of the association of each imaging feature to each pathway.

3 greatest P-values per imaging feature	1	2	3
T2 Signal Intensity	Pancreatic Adenocarcinoma Signaling 6.177	Melanoma Signaling 4.405	Non-Small Cell Lung Cancer Signaling 4.111
T2 Heterogeneity	UVB-Induced MAPK Signaling 6.245	EGF Signaling 6.206	ErbB Signaling 5.725
Skin Thickening	Epithelial Adherens Junction Signaling 8.957	Regulation of the Epithelial-Mesenchymal Transition Pathway 8.282	Pancreatic Adenocarcinoma Signaling 5.692
Skin Invasion	14-3-3-mediated Signaling 10.378	Cell Cycle: G2/M DNA Damage Checkpoint Regulation 7.914	UVB-Induced MAPK Signaling 7.385
Irregular Shape	UVC-Induced MAPK Signaling 6.845	EGF Signaling 6.206	STAT3 Pathway 6.112
Rim Enhancement	ATM Signaling 8.26	AMPK Signaling 6.385	Cell Cycle: G2/M DNA Damage Checkpoint Regulation 5.037
Pectoral Invasion	PI3K/AKT Signaling 12.834	Neuregulin Signaling 10.295	p70S6K Signaling 9.069
Non-Mass Heterogeneous Internal Enhancement	ILK Signaling 7.812	PI3K/AKT Signaling 6.646	Endometrial Cancer Signaling 5.511
Non-Mass Clustered Ring Internal Enhancement	ATM Signaling 4.078	CDK5 Signaling 3.892	B Cell Receptor Signaling 3.349
Non-Mass Clumped Internal Enhancement	DNA Double-Strand Break Repair by Homologous Recombination 3.181	DNA Double-Strand Break Repair by Non-Homologous End Joining 3.181	DNA damage-induced 14-3-3σ Signaling 3.049
Regional Non-Mass Distribution	Acute Myeloid Leukemia Signaling 3.745	Cancer Drug Resistance By Drug Efflux 1.94	autophagy 1.853
Multiple Regions Non-Mass Distribution	PI3K/AKT Signaling 4.471	IL-8 Signaling 4.068	CD27 Signaling in Lymphocytes 2.311
Linear Non-Mass Distribution	ErbB2-ErbB3 Signaling 6.883	ErbB Signaling 6.421	Relaxin Signaling 5.845
Focal Non-Mass Distribution	UVC-Induced MAPK Signaling 11.037	Cancer Drug Resistance By Drug Efflux 10.613	AMPK Signaling 10.337
Diffuse Non-Mass Distribution	DNA Double-Strand Break Repair by Homologous Recombination 5.395	Role of BRCA1 in DNA Damage Response 3.879	ATM Signaling 3.857
Nipple Retraction	PI3K/AKT Signaling 6.112	UVB-Induced MAPK Signaling 4.246	FLT3 Signaling in Hematopoietic Progenitor Cells 4.025
Nipple Invasion	Estrogen-mediated S-phase Entry 2.346	Induction of Apoptosis by HIV1 1.949	Lymphotoxin β Receptor Signaling 1.901
Margin	Molecular Mechanisms of Cancer 3.746	DNA damage-induced 14-3-3σ Signaling 2.205	GADD45 Signaling 2.205
Lesion Size	Hereditary Breast Cancer Signaling 7.625	PI3K/AKT Signaling 5.976	Insulin Receptor Signaling 5.753
Heterogeneous Enhancement Intensity	Prolactin Signaling 6.64	Th1 Pathway 6.001	Th1 and Th2 Activation Pathway 5.588
Fibroglandular	UVC-Induced MAPK Signaling 13.629	UVB-Induced MAPK Signaling 12.176	Neuregulin Signaling 11.271
Extent Heterogeneity	Prostate Cancer Signaling 7.076	UVB-Induced MAPK Signaling 4.546	FLT3 Signaling in Hematopoietic Progenitor Cells 4.325
Extent - Multi-focal	CNTF Signaling 4.587	UVB-Induced MAPK Signaling 4.546	EGF Signaling 4.52
Extent - Multi-centric	Hepatic Fibrosis / Hepatic Stellate Cell Activation 3.359	Tumoricidal Function of Hepatic Natural Killer Cells 2.346	Coagulation System 2.182
Edema	Hereditary Breast Cancer Signaling 4.797	AMPK Signaling 4.425	Endometrial Cancer Signaling 3.607
Dark Internal Septum	Huntington's Disease Signaling 3.418	Glucocorticoid Receptor Signaling 3.267	Parkinson's Signaling 2.646
Background	Insulin Receptor Signaling 5.753	Molecular Mechanisms of Cancer 5.539	NF-κB Signaling 5.331
Axillary Lymphadenopathy	ERK/MAPK Signaling 4.8	EGF Signaling 3.824	Erythropoietin Signaling 3.693
Associated Non-Mass Enhancement	Pancreatic Adenocarcinoma Signaling 7.206	UVC-Induced MAPK Signaling 6.399	Cancer Drug Resistance By Drug Efflux 6.194