Table 3. Relationship between hepatitis B virus infection and site-specific cancers in women.
Cancer Site | Number of patients in the pooled cohort | Matched analysis* | |||
---|---|---|---|---|---|
Total | HBsAg+ | OR | 95% CI | P value | |
Stomach | 5,373 | 184 | 0.98 | 0.79–1.21 | 0.825 |
Colon | 2,921 | 118 | 1.15 | 0.87–1.52 | 0.320 |
Rectum | 1,842 | 68 | 1.29 | 0.89–1.88 | 0.183 |
Bile duct | 1,584 | 94 | 1.71 | 1.16–2.51 | 0.007 |
Pancreas | 1,499 | 55 | 0.93 | 0.60–1.44 | 0.739 |
Esophagus | 62 | 1 | 0.50 | 0.05–5.51 | 0.571 |
Gallbladder | 691 | 22 | 1.06 | 0.55–2.05 | 0.866 |
Lung | 2,653 | 122 | 1.79 | 1.32–2.44 | <0.001 |
Kidney | 674 | 27 | 1.16 | 0.63–2.14 | 0.640 |
Bladder | 289 | 6 | 1.20 | 0.37–3.93 | 0.763 |
Breast | 12,487 | 482 | 1.16 | 1.02–1.32 | 0.033 |
Cervix | 2,370 | 118 | 1.49 | 1.11–2.00 | 0.007 |
Uterus | 1,102 | 66 | 1.69 | 1.09–2.61 | 0.019 |
Ovary | 1,048 | 53 | 0.67 | 0.34–1.31 | 0.240 |
Brain | 2,484 | 101 | 1.09 | 0.82–1.47 | 0.549 |
Head and neck | 427 | 18 | 1.33 | 0.63–2.82 | 0.451 |
Thyroid | 9,815 | 419 | 1.49 | 1.28–1.74 | <0.001 |
Skin | 245 | 11 | 1.83 | 0.68–4.96 | 0.232 |
Hematologic disease | 744 | 37 | 1.26 | 0.73–2.18 | 0.406 |
Lymphoma | 974 | 83 | 3.04 | 1.92–4.82 | <0.001 |
Bone and soft tissue | 192 | 6 | 2.00 | 0.50–8.00 | 0.327 |
CI = confidence interval; HBsAg = hepatitis B virus surface antigen; OR = odds ratio.
*Controls were matched to cases by age, hypertension, diabetes, alcohol consumption, smoking status, and serum cholesterol level.