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. 2018 Mar 15;13(3):e0193232. doi: 10.1371/journal.pone.0193232

Table 3. Relationship between hepatitis B virus infection and site-specific cancers in women.

Cancer Site Number of patients in the pooled cohort Matched analysis*
Total HBsAg+ OR 95% CI P value
Stomach 5,373 184 0.98 0.79–1.21 0.825
Colon 2,921 118 1.15 0.87–1.52 0.320
Rectum 1,842 68 1.29 0.89–1.88 0.183
Bile duct 1,584 94 1.71 1.16–2.51 0.007
Pancreas 1,499 55 0.93 0.60–1.44 0.739
Esophagus 62 1 0.50 0.05–5.51 0.571
Gallbladder 691 22 1.06 0.55–2.05 0.866
Lung 2,653 122 1.79 1.32–2.44 <0.001
Kidney 674 27 1.16 0.63–2.14 0.640
Bladder 289 6 1.20 0.37–3.93 0.763
Breast 12,487 482 1.16 1.02–1.32 0.033
Cervix 2,370 118 1.49 1.11–2.00 0.007
Uterus 1,102 66 1.69 1.09–2.61 0.019
Ovary 1,048 53 0.67 0.34–1.31 0.240
Brain 2,484 101 1.09 0.82–1.47 0.549
Head and neck 427 18 1.33 0.63–2.82 0.451
Thyroid 9,815 419 1.49 1.28–1.74 <0.001
Skin 245 11 1.83 0.68–4.96 0.232
Hematologic disease 744 37 1.26 0.73–2.18 0.406
Lymphoma 974 83 3.04 1.92–4.82 <0.001
Bone and soft tissue 192 6 2.00 0.50–8.00 0.327

CI = confidence interval; HBsAg = hepatitis B virus surface antigen; OR = odds ratio.

*Controls were matched to cases by age, hypertension, diabetes, alcohol consumption, smoking status, and serum cholesterol level.