Table 2. Laboratory data and bone mineral density (BMD) at baseline.
| Total | Denosumab | Alendronate | P | |
|---|---|---|---|---|
| (N = 28) | (N = 14) | (N = 14) | ||
| Serum biochemical markers | ||||
| Albumin (g/dL) | 3.9 (2.8–4.3) | 4.0 (2.9–4.2) | 3.6 (2.3–4.3) | 0.764 |
| eGFR (ml/min/1.73m2) | 56.0 (44.9–72.4) | 61.1 (46.2–86.1) | 49.0 (44.1–61.2) | 0.085 |
| Corrected Ca (mg/dl) | 9.6 ± 0.5 | 9.6 ± 0.5 | 9.6 ± 0.5 | 0.795 |
| P (mg/dL) | 3.2 ± 0.6 | 3.3 ± 0.5 | 3.2± 0.6 | 0.716 |
| Uric Acid | 5.7 ± 1.3 | 5.6 ± 1.6 | 5.7 ± 1.1 | 0.760 |
| ALP (U/L) | 226.1 ± 69.6 | 219.0 ± 56.3 | 233.2 ± 82.4 | 0.598 |
| TG (mg/dL) | 169.4 ± 121.8 | 154.6 ± 75.6 | 184.1 ± 156.9 | 0.532 |
| TC (mg/dL) | 235.8 ± 117.5 | 222.3 ± 121.2 | 249.3 ± 116.7 | 0.552 |
| HDL-C (mg/dL) | 62.4 ± 16.4 | 59.9 ± 15.3 | 65.0 ± 17.6 | 0.423 |
| LDL-C (mg/dL) | 113.5 (86.8–138.3) | 105.0 (81.3–126.3) | 124.0 (100.2–170.8) | 0.102 |
| LDL / HDL ratio | 1.8 (1.2–2.6) | 1.8 (1.2–2.5) | 2.0 (1.3–3.0) | 0.629 |
| HbA1c | 5.9 ± 0.6 | 5.9 ± 0.7 | 5.9 ± 0.5 | 0.798 |
| Intact PTH (pg/mL) | 44.2 ± 25.0 | 41.5 ± 21.1 | 46.9 ± 28.9 | 0.580 |
| TRACP-5b (mU/dL) | 339.0 (248.0–543.5) | 398.0 (248.0–528.5) | 332.0 (204.5–591.3) | 0.800 |
| Total P1NP (ug/L) | 36.4 (25.3–52.7) | 43.0 (26.7–52.8) | 30.4 (23.9–54.6) | 0.783 |
| BAP (ug/L) | 10.4 (7.1–13.7) | 10.5 (7.2–14.3) | 10.4 (6.7–11.6) | 0.645 |
| 1,25(OH) 2 VitD | 43.6 ± 21.1 | 39.1 ± 19.1 | 47.6 ± 22.8 | 0.295 |
| Pentosidine (ug/L) | 0.04 ± 0.02 | 0.04 ± 0.02 | 0.04 ± 0.02 | 0.872 |
| Homocysteine (nmol/mL) | 13.3 (11.3–19.0) | 13.8 ± 5.0 | 24.8 ± 21.8 | 0.232 |
| Bone mineral density | ||||
| Lumbar spine | ||||
| Measurement—g/cm 2 | 0.889 (0.787–1.022) | 0.895 (0.745–1.060) | 0.875 (0.821–1.045) | 0.918 |
| T score | -1.3 (-2.1–-0.2) | -1.3 (-2.5–0.3) | -1.2 (-1.9–-0.4) | 0.918 |
| Femoral neck | ||||
| Measurement—g/cm 2 | 0.676 (0.532–0.716) | 0.672 ± 0.17 | 0.627 ± 0.11 | 0.715 |
| T score | -1.5 ± 1.2 | -1.3 ± 1.3 | -1.7 ± 0.9 | 0.378 |
| Ultra-distal radius | ||||
| Measurement—g/cm 2 | 0.400 ± 0.11 | 0.409 ± 0.12 | 0.390 ± 0.09 | 0.323 |
| T score | -1.7 ± 1.5 | -1.5 ± 1.6 | -1.9 ± 1.5 | 0.473 |
Data are presented as mean ± SD, median (range from 25th to 75th percentile). Abbreviations: eGFR, estimated glemerular filtration rate; P, phosphate; ALP, alkaline phosphatase; TG, triglyceride; TC, total cholesterol; HDL-C, HDL-cholesterol; LDL-C, LDL-cholesterol; HbA1c, glycated hemoglobin; intact PTH, intact parathyroid hormone; TRACP-5b, tartrate-resistant acid phosphatase 5b; t-P1NP, total- type I collagen N-terminal propeptide; BAP, bone-specific alkaline phosphatase