Table 3.
Cross-resistance profile of resistant strains. MICs were measured on solid medium in 96-well format. MICs were defined as the minimum concentration required to inhibit growth completely. *AN6291-RM1 had a large deletion encompassing mce3R.
| Strain | Gene | Mutation | Amino acid change | MIC solid (μM) |
||
|---|---|---|---|---|---|---|
| AN6288 | AN6291 | AN11987 | ||||
| H37Rv | 12.5 | 12.5 | 0.2 | |||
| AN6288-RM1 | ndh | 667C > A | P223T | 50 | 50 | 25 |
| AN6288-RM2 | ndh | 1262 T > C | F421S | 50 | 50 | 3.1 |
| AN6291-RM1 | * | Rv1948c-Rv1970 deletion | 50 | 100 | 3.1 | |
| AN6291-RM5 | mce3R | 563G > T | C188F | 50 | 100 | 3.1 |
| AN6291-RM6 | mce3R | 555C > A | Y185* | 50 | 100 | 3.1 |