Table 4. Neuronal routes different Lagos bat viruses travelled from the intracranial inoculation site to the periphery.
LBV strain(s) | Peripheral location | Deduced route for centrifugal spread of LBVs from intracranial inoculation site to periphery | ||||
---|---|---|---|---|---|---|
Origin in CNS | Route (nerves & ganglia) | Characteristics of neuronal route | ||||
Specific nucleus | General location of nucleus in CNS | Number of synapses to pass | Division of nervous system involved | |||
Ghana | Tongue ganglion | Salivatory | Motor medulla | Chorda tympani and glossopharyngeal nerves | 1 | Parasympathetic motor |
Ghana | Otic ganglion (salivary gland) | Inferior salivatory | Motor medulla | Chorda tympani and glossopharyngeal nerves | 1 | Parasympathetic motor |
Ghana, Senegal | Cardiac plexi at base of hearta | Dorsal motor nucleus of vagus nerve | Motor medulla | Vagus nerve | 1 | Parasympathetic motor |
Cranial four to five segments thoracic spinal cord | Spinal cord | Cervical paravertebral sympathetic trunk and postganglionic fibers | 2 | Sympathetic motor | ||
Ghana | Myenteric plexi of duodenum and jejunuma | Dorsal motor nucleus of vagus nerve | Motor medulla | Vagus nerve | 1 | Parasympathetic motor |
Dorsal horn spinal cord | Spinal cord | Splanchnic nerve, celiac ganglion, and postganglionic fibers | 2 | Sympathetic motor | ||
Ghana, Senegal | Taste buds on tongue | Solitary tract | Sensory medulla | Geniculate, petrosal and nodosal ganglia | 2 | Special sensory |
a More than one route possible because of innervation of the nervous plexi by both parasympathetic and sympathetic nervous system.