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. Author manuscript; available in PMC: 2018 Mar 15.
Published in final edited form as: Mol Cell. 2017 Dec 21;69(2):165–168. doi: 10.1016/j.molcel.2017.11.028

Figure 1. Related Mechanistic Features between Animal and Fungal Clocks.

Figure 1

Beginning in the upper left, parts of the heterodimeric TF (oval and circle) interact via PAS domains and bind to the promoters of genes encoding negative elements. The negative-element proteins (yellow and red) have both structured (hexagon and pentagon) and flexible or unstructured regions (clouds). The negative elements form a complex in the nucleus with other proteins (gray background shapes) including CK1 and interact with the TF, causing it to be inactivated. Multisite clock-signaling phosphorylations (P) of the negative elements lead to their inactivation as repressors, and to dissociation, releasing the heterodimeric TF to restart the cycle.