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. Author manuscript; available in PMC: 2018 Mar 15.
Published in final edited form as: Addiction. 2017 Jun 23;112(11):2053–2063. doi: 10.1111/add.13880

Table 3.

Age-specific estimates of the AAF of breast cancer cases, United States 1999–2002.

Method/substrata NHSDA NAS NESARC



AAF (%) 95% CI AAF (%) 95% CI AAF (%) 95% CI
Unadjusted (gamma)
 Females, 18–25 7.84 (6.73–8.94) 13.51 (2.49–17.63) 9.90 (5.81–13.36)
 Females, 26–34 2.78 (2.63–3.30) 1.10 (0.61–1.48) 1.26 (0.58–2.50)
 Females, 35–49 3.12 (2.52–4.08) 1.64 (0.77–4.01) 3.17 (0.95–6.03)
 Females, 50+ 1.73 (1.70–1.96) 0.42 (0.29–0.51) 0.57 (0.19–1.05)
Unadjusted (best-fitting)
 Females, 18–25 9.07a (8.79–9.37) 7.76a (6.06–9.68) 9.35a (8.60–10.01)
 Females, 26–34 5.00a (4.68–5.35) 1.77b (1.27–2.31) 6.37a (5.86–6.89)
 Females, 35–49 5.15a (4.83–5.46) 3.47a (2.79–4.20) 7.13a (6.74–7.54)
 Females, 50+ 3.25a (3.01–3.56) 1.04c (0.75–1.42) 4.85a (4.63–5.14)
Adjusted (Rehm et al.)
 Females, 18–25 28.36 (27.99–28.70) 31.13 (27.68–31.84) 25.82 (19.26–30.39)
 Females, 26–34 18.27 (17.80–18.62) 8.31 (6.04–10.16) 9.48 (5.96–13.61)
 Females, 35–49 19.16 (18.48–19.60) 14.67 (10.40–16.61) 14.32 (7.81–20.87)
 Females, 50+ 10.49 (9.82–10.91) 3.03 (2.44–3.70) 6.22 (4.85–7.69)
Adjusted (gamma)
 Females, 18–25 28.66 (28.37–28.94) 23.32 (20.18–25.61) 24.17 (23.15–24.96)
 Females, 26–34 17.88 (17.12–18.33) 9.60 (8.18–10.92) 13.47 (11.67–14.62)
 Females, 35–49 19.22 (18.68–19.61) 14.14 (12.36–15.09) 17.26 (15.43–18.13)
 Females, 50+ 10.12 (9.28–10.69) 3.26 (2.65–3.86) 9.20 (8.53–9.79)
Adjusted (best-fitting)
 Female, 18–25 19.33a (18.98–19.68) 14.51a (12.62–16.23) 13.18a (12.41–13.95)
 Females, 26–34 12.72a (12.11–13.32) 7.66b (5.51–10.70) 9.93a (9.29–10.59)
 Females, 35–49 12.63a (12.08–13.17) 8.05a (6.92–9.15) 10.67a (10.18–11.14)
 Females, 50+ 8.31a (7.69–8.89) 2.77c (2.12–3.47) 7.24a (6.87–7.59)

AAF = alcohol-attributable fraction; CI = confidence interval; NAS = National Alcohol Survey; NESARC = National Epidemiologic Survey of Alcohol and Related Conditions; NHSDA = National Household Survey of Drug Abuse; CI = confidence interval. The best-fitting distribution represents the distribution with the smallest calculated Kolmogorov–Smirnov statistic. Kolmogorov–Smirnov statistics indicate the absolute value of the maximum deviation across the assumed cumulative distribution function and the empirical distribution function. Thus, smaller Kolmogorov–Smirnov statistics indicate a closer fit to the underlying data. All estimates are weighted to make them nationally representative.

a

Best-fitting distribution for this substratum was the lognormal distribution.

b

Best-fitting distribution for this substratum was the Weibull distribution.

c

Best-fitting distribution for this substratum was the generalized gamma distribution.