Table 4.
Predictor Variables Specific to aMCI or naMCI (Listed in order of from high to low weights)
| Variable | Description | Direction |
|---|---|---|
| Table 4a. Predictor Variables Specific to aMCI | ||
| NACCAGEB | Age at assessment | + |
| NACCZLMD | Age-, sex-, and education-adjusted z-score for Logical Memory 1A-Delayed total | _ |
| DECCLIN | Does the clinician believe there has been a current meaningful decline in the subject’s memory, non-memory cognitive abilities, behavior, or ability to manage his/her affairs, or have there been motor/movement changes relative to previously attained abilities? (Yes) | + |
| TRAVEL | In the past four weeks, did the subject have any difficulty or need help with traveling out of the neighborhood, driving, or arranging to take public transportation. | + |
| NACCZLMI | Age-, sex-, and education-adjusted z-score for Logical Memory 1A-Immediate total number of items recalled | _ |
| NACCLEVB | Levy B score for levodopa-nonresponsive symptoms: UPDRS non- dopaminergic deficiency. | + |
| NACCMND | Subjects for whom a clinical diagnosis of “motor neuron disease” is indicated in the form (Yes) | + |
| Table 4b. Predictor Variables Specific to naMCI | ||
| MOFALLS | Does the subject fall more than usual? (Yes) | + |
| PRESTAT | Presumed disease status at enrollment. (case or proband) | − |
| MOSLOW | Slowness (Has the subject noticeably slowed down in walking or moving or handwriting, other than due to an injury or illness? Has his/her facial expression changed, or become more “wooden” or masked and unexpressive?) (Yes) | + |
| NACCZBOS | The Boston Naming Test Age-, sex-, and education-adjusted z-score for the Boston Naming Test score |
− |
| NACCZDBL | The length on the Digit Span Backward test Age-, sex-, and education-adjusted z-score for Digit Span Backward length |
− |
| JUDGMENT | Judgment & problem solving in CDR | + |
| MOTREM | Tremor (Has the subject had rhythmic shaking, especially in the hands, arms, legs, head, mouth or tongue?) (Yes) | + |
| Table 4c. Predictor variables common to both aMCI and naMCI incidence (In the order of from high to low weights appeared for aMCI incidence) | ||
| COGSTAT | Based on the UDS neuropsychological examination, the subject’s cognitive status is deemed: 1 = Better than normal for age 2 = Normal for age 3 = One or two test scores abnormal 4 = Three or more scores are abnormal or lower than expected |
+ |
| DECIN | Does the informant report a decline in subject’s memory relative to previously attained abilities? (Yes) | + |
| NACCZVEG | Total number of vegetables named in 60 seconds Age-, sex-, and education-adjusted z-score for Category ‘vegetables’ |
− |
| NACCZWAI | Age-, sex-, and education-adjusted z-score for the WAIS-R Digit Symbol score | − |
| NACCZTRB | Age-, sex-, and education-adjusted z-score for the Trail B score | − |
| CDRSUM | Clinical Dementia Rating Sum of Box | + |
| MEMORY | Memory in CDR | + |
| NACCZANI | Total number of animals named in 60 seconds Age-, sex-, and education-adjusted z-score for Category ‘animals’ |
− |
| Table 4d. Variables selected only when outcome is overall MCI | ||
| SPEECH | 0 = Normal. 1 = Slight loss of expression, diction and/or volume. 2 = Monotone, slurred but understandable; moderately impaired. 3 = Marked impairment, difficult to understand. 4 = Unintelligible. |
+ |
| TAXES | In the past four weeks, did the subject have any difficulty or need help with assembling tax records, business affairs, or other papers |
+ |
| BILLS | In the past four weeks, did the subject have any difficulty or need help with writing checks, paying bills, or balancing a checkbook. |
+ |
*
: The variables in Table 4c. are in the order of from high to low weights appeared for aMCI incidence. Please check supplemental material for the full table with variable description. The symbol +/− indicates the positive/negative effects of the variables.