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. Author manuscript; available in PMC: 2018 Mar 15.
Published in final edited form as: Stem Cells. 2009 Aug;27(8):1734–1740. doi: 10.1002/stem.102

Figure 5.

Figure 5

Therapeutic effect of neurosphere-pulsed DC against intracranial 9L tumor in adult rats. Rats were injected intracranially with 25000 9L glioma cells on day 0 and were vaccinated s.c. on days 7, 14, and 21 with different tumor antigen pulsed dendritic cell vaccines: control (DC only), monolayer, daughter cells, and neurospheres (n=10 for each group). Kaplan-Meier survival curve showed that rats treated with 9L neurosphere lysate-pulsed DC have longer survival than the other groups (** p=0.0015). The surviving animals with CSC vaccination were sacrificed after 70 days and slowly growing brain tumors were detected.