Fig 3.

Syntheses of nanoemulsions-based drug carriers in microfluidic platforms. (A-1) Schematic of LNP formulation process employing a staggered herringbone micromixer. (A-2) Cryo-TEM micrographs of limit size LNP with the total lipid concentration in the ethanol phase of 10 mg/mL. Adapted from Zhigaltsev et al. [132]. Copyright 2012 American Chemical Society. (B) Schematic of the PFPE-tyramide nanoemulsions for imaging-guided drug delivery. FSDCs cellular uptake of nanoemulsions visualized by NIR microscopy (left) and NIR fluorescence imaging (at 800 nm, right). Adapted from Hanlon et al. [139]. Copyright 2012 Elsevier.