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. Author manuscript; available in PMC: 2018 Jul 11.
Published in final edited form as: Oncogene. 2018 Jan 11;37(11):1457–1471. doi: 10.1038/s41388-017-0049-3

Fig. 6. Inhibition of LPA signaling suppresses proliferation of GBM PDXs in vivo.

Fig. 6

(A) Representative images of mice subcutaneously injected with GBM6 (left panel) and GBM12 (right panel) and administered with vehicle or 30mg/kg/day Ki16425. (B, C) Analysis of tumor growth as in (A) for GBM6 (B) and GBM12 (C); 5 mice per group; two-way ANOVA with Sidak’s post hoc test, p<0.05. (D, E) Analysis of GBM6 (D) and GBM12 (E) terminal tumor weight; 5 tumors per group; Student’s t-test, p<0.05. (F, G) Representative images of GBM6 (F) and GBM12 (G), stained with DAPI; arrowheads indicate mitotic cells; scale bar – 20μm. (H, I) Quantification of mitotic figures as in (F, G) for GBM6 (H) and GBM12 (I); at least 1000 cells within 10 random fields per group; Student’s t-test, p<0.05.