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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Eur J Pain. 2017 Oct 16;22(4):679–690. doi: 10.1002/ejp.1132

Fig. 1.

Fig. 1

Effect of EA on paclitaxel-induced mechanical hyperalgesia and allodynia (n = 6/group). The mechanical response was evoked using von Frey filaments with bending forces 2 (A), 4 (B), 8 (C) and 15 g (D). The EA treatment (10 Hz, 2 mA / 30 min, 0.4 ms pulse) was given on days 14, 16, 18, 20, 22, 24 and 26 after paclitaxel injection. Paclitaxel-injected rats with sham EA treatment (∆) showed significantly higher frequencies of mechanical responses than vehicle-injected ones with sham EA (○) from days 13–47 post-paclitaxel injection. Rats with paclitaxel and EA treatment (▲) showed significantly lower frequencies of mechanical responses than those with paclitaxel and sham EA control (∆). The EA inhibition of mechanical responses persisted up to day 47, the longest time point observed in the experiment. Vehicle-injected rats given EA treatment (●) showed similar mechanical responses as did vehicle-injected rats with sham EA (○). This suggests that EA did not influence the mechanical sensitivity in healthy condition. *P<0.05, **P<0.01, ***P<0.001 vs vehicle + sham; #P<0.05, ##P<0.01, ###P<0.001 vs paclitaxel + EA.