Table 2.

Estimated cost savings with nondaily PrEP.

Country	Population	Median days/week have sex	Percentage of costs attributable to PrEP drugs	Cost reductions with EDD	Cost reductions with TDD	Cost reductions with IPERGAY regimen
United States	MSM (lower activity)	1	92–96%	66–69%	53–69%	39–55%
United States	MSM (higher activity)	1.5	92–96%	39–69%	39–69%	0–55%
France	MSM	1 [using distribution]	96%	69% [69–73%]	55–69% [52–64%]	41–55% [50–64%]
Kenya	MSM	1	21%	15%	12–15%	9–12%
South Africa	Heterosexual (lower activity)	1	47–53%	34–38%	27–38%	20–30%
South Africa	Heterosexual (higher activity)	2	47–53%	20–30%	20–38%	0–23%

EDD, event-driven PrEP, TDD, time-driven PrEP (regimens from HPTN 067/ADAPT). Figures in italics were estimated using the full distribution of sex-days per week across the population, rather than the median.