Table I.
Blood reticulocyte and micronucleated reticulocyte measurements.
| Study | Treatment (mg/kg/day) | Treatment Duration (Days) | Blood Harvest Day | %RET | %MN-RET |
|---|---|---|---|---|---|
| DEN, short-term | 0 | 3 | 4 | 4.84, 4.99, 6.23, 5.69, 6.93, 7.21 | 0.15, 0.12, 0.11, 0.19, 0.07, 0.12 |
| 10 | 3 | 4 | 5.87, 5.70, 6.00, 6.56, 5.64, 6.38 | 0.11, 0.11, 0.10, 0.08, 0.10, 0.11 | |
| 20 | 3 | 4 | 4.39, 4.92, 5.22, 4.83, 5.46, 5.60 * | 0.10, 0.06, 0.14, 0.10, 0.11, 0.14 | |
| 40 | 3 | 4 | 3.54, 3.22, 3.26, 3.32, 3.22, 4.02 * | 0.17, 0.11, 0.10, 0.12, 0.08, 0.17 | |
| DEN, protracted | 0 | 14 | 15 | 3.20, 3.30, 2.81, 3.56, 2.69 | 0.11, 0.07, 0.18, 0.05, 0.12 |
| 5 | 14 | 15 | 2.02, 3.64, 2.65, 2.55, 1.53 | 0.14, 0.23, 0.09, 0.08, 0.05 | |
| 10 | 14 | 15 | 2.01, 1.81, 1.72, 1.85, 1.59 * | 0.11, 0.06, 0.07, 0.10, 0.09 | |
| 20 | 14 | 15 | 1.08, 1.37, 1.04, 0.34, 1.06 * | 0.15, 0.10, 0.10, 0.14, 0.17 | |
| QUIN, short-term | 0 | 3 | 4 | 5.45, 5.58, 4.52, 4.81, 4.53, 5.84 | 0.06, 0.12, 0.07, 0.18, 0.10, 0.10 |
| 75 | 3 | 4 | 2.35, 3.18, 3.31, 3.94, 3.05, 1.9 * | 0.06, 0.10, 0.03, 0.10, 0.04 | |
| 100 | 3 | 4 | 1.55, 1.76, 2.12, 4.49, 4.11, 3.38 * | 0.07, 0.09, 0.09, 0.11, 0.10, 0.06 | |
| 125 | 3 | 4 | 2.82, 1.42, 4.25, 4.64, 1.44, 3.45 * | 0.06, 0.11, 0.09, 0.09, 0.07, 0.05 | |
| QUIN, protracted | 0 | 14 | 15 | 2.79, 3.36, 2.36, 2.18, 2.18, 2.53 | 0.08, 0.10, 0.07, 0.05, 0.07, 0.12 |
| 50 | 14 | 15 | 2.57, 2.29, 2.36, 2.13, 3.11, 2.34 | 0.09, 0.15, 0.12, 0.07, 0.12, 0.09 | |
| 75 | 14 | 15 | 2.83, 3.23, 2.20, 2.79, 1.67, 2.96 | 0.06, 0.11, 0.07, 0.09, 0.13, 0.18 | |
| 100 | 14 | 15 | 3.15, 2.91, 3.14, 3.50, 3.09, 3.08 | 0.11, 0.09, 0.09, 0.07, 0.11, 0.15 |
Abbreviations: DEN = diethylnitroamine; QUIN = quinoline; %RET = percent reticulocytes; %MN-RET = percent micronucleated reticulocytes.
*
= Treatment group is significantly different from concurrent vehicle control, p < 0.05, two-sided Dunnett’s test in the case of %RET, one-sided in the case of %MN-RET.