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. Author manuscript; available in PMC: 2018 Aug 28.
Published in final edited form as: Nature. 2018 Feb 28;555(7696):371–376. doi: 10.1038/nature25795

Figure 2. Candidate driver genes in pediatric cancer.

Figure 2

a, Top 100 recurrently mutated genes: case count for each histotype is shown in the same color as the legend. An asterisk (*) indicates gene not reported in prior adult pan-cancer analyses. b, Statistically significant pairwise relationships (P<0.05; two-sided Fisher’s Exact test) for co-occurrence (red color) or exclusivity (blue color) in each histotype. Gene pairs with Q<0.05 are colored dark red (co-occurring) or dark blue (exclusive) to account for false discovery rate. Significance detected only in WGS+WES samples is marked with an asterisk (*). Number of mutated samples are labeled in parenthesis.