Fig. 2.

Effect of surface modification on magnetic nanoparticle on hypothermia to reduce tumor size. a Schematic presentation showing the composition of the 4-tetracarboxyphenyl porphyrin (TCPP)-labeled, dopamine-anchored tetraethylene glycol ligands coated bimagnetic Fe/Fe3O4 nanoparticles; b Graph illustrating the temperature profiles at the MNP injection site in the body core during alternating magnetic field (AMF) exposure, which is measured with a fiber optic temperature probe; c In vivo antitumor response after intratumoral injection of MNPs followed by AMF treatments. Graph demonstrates the relative changes in average tumor volumes over time of B16–F10 tumor bearing mice that were later injected with either saline or MNP intratumorally with or without AMF treatments⁶³