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. 2018 Mar 15;8:4607. doi: 10.1038/s41598-018-22920-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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H. polygyrus infection promotes a strong type 2 immune response. Real time qPCR analysis shows a clear suppression in the T-bet and RORγt mRNAs expression (a and b) and increase in the expression of GATA3 and Foxp3 mRNAs (c and d) in the MLN cells from HFD-fed H. polygyrus-infected mice. H. polygyrus-infected obese mice showed decreases in IFN-γ and IL-17 secretions in the supernatant of cultured MLN cells (e and f). H. polygyrus-infected obese mice had higher production of cytokines IL-4 and IL-10 in MLN (g and h). H. polygyrus-infected obese mice had increased levels of serum IgE (i) and IgG1 (j) and a decreased IgG2a level (k). (n = 5–6; *p < 0.05; two-tailed Student’s t-test).