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. 2018 Mar 15;8:4619. doi: 10.1038/s41598-018-22620-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mutations frequencies in unique HCV sequences obtained from supernatants of treated and non-treated J6/JFH1 cell cultures. All nucleotide substitutions identified in unique sequences were scored and normalized to the number of each nucleotide in the baseline reference sequence. (a) Mutation frequencies from day 9 samples treated with RBV. (b) Mutation frequencies from day 9 samples treated with RMP. (c) Mutation frequencies from day 9 samples treated with RTP. Drug concentrations are indicated by color legends in each panel. Bars represent overall frequencies calculated from unique sequences. Sample sizes: n = 37 (NTC); n = 115 (RBV); n = 76 (RMP), n = 61 (RTP).