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. 2018 Mar 15;8:4643. doi: 10.1038/s41598-018-22850-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental outline for measuring eye, brain and behavioral changes in the D2 mouse model of chronic glaucoma and the wild type B6 mice across age. Vertical arrows on the horizontal timelines represent intraocular pressure (IOP) measurements by tonometry (solid blue), ocular anatomical T2-weighted MRI (solid purple), brain diffusion tensor MRI (DTI) (hollow cyan), visuomotor behavioral assessments by optokinetics (solid light blue), and manganese (Mn)-enhanced MRI of anterograde transport (hollow dark blue). The numbers on top of the vertical arrows represent the sample size (n) of the D2 or B6 mice for each modality at each age. In Group 1, additional IOP measurements were performed in between 7, 9 and 12 mos for more precise longitudinal monitoring of the progression of IOP elevation in the same animals (Fig. 2a).