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. 2018 Mar 15;8:4643. doi: 10.1038/s41598-018-22850-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Intraocular pressure (IOP) measurements and optokinetic assessments of D2 and B6 mice across age. (a) IOP profiles of the D2 (dashed line) and B6 (solid line) mice in Group 1 from 5 to 12 mos. (b) IOP profiles in Groups 1–4 at 5, 7, 9 and 12 mos respectively. (c) Visual acuity of the D2 and B6 mice at 5 to 12 mos via optokinetic visuomotor behavioral assessments. Post-hoc Tukey’s tests between ages in the D2 mice: ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, ^####p < 0.0001; between D2 and B6 mice: *p < 0.05; ****p < 0.0001. No significant difference was observed between ages in the B6 mice. Error bars represent ± standard deviation.