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. 2018 Mar 15;9:1090. doi: 10.1038/s41467-018-03424-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Practical guidelines for module detection in gene expression data. Module detection in gene expression data has three main applications (left; panel a). For each application, we suggest different module detection methods (b), which in turn influences the way parameters are estimated (c), how the modules can be visualized (d), and how they can be functionally interpreted (e)