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. 2018 Mar 15;8:4569. doi: 10.1038/s41598-018-23120-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cytotoxic activity of cytotoxic T cells generated from hiPSDCs-CEA. CD8⁺ cytotoxic T cells were sorted using an autoMACS Pro Separator after three cycles of stimulation of autologous peripheral blood mononuclear cells by genetically modified DCs, and the cytotoxic activity was tested using a 4-h ⁵¹Cr release assay. Cytotoxic T cells induced by hiPSDCs-CEA from each of the three HLA-A24-positive donors exhibited cytotoxic activity against LCLs-CEA and LCLs-CEA652, whereas they exhibited no cytotoxicity against LCLs-LacZ. Cytotoxic T cells induced by hiPSDCs-LacZ from each HLA-A24-positive donor exhibited no cytotoxic activity against LCLs-CEA, LCLs-CEA652, or LCLs-LacZ.