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. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195

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Copyright © 2018 Wang, Zhang, Wu, Wang, Chen, Chen, Zhang, Chen, Geng, Xu, Dai, Li and Pan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EGCG modulated TTC39B expression and its target gene in ApoE^-^/^- mice. ApoE^-/- mice were fed with HFD and were treated daily with or without EGCG for 18 weeks by oral gavage, the protein, or/and mRNA levels of TTC3B, and target genes in liver were detected as described in the section “Materials and Methods.” (A) Quantitative analysis of mRNA levels of hepatic Ttc39b, Lxrα, Lxrβ, Abcg5, Abcg8, Abca1, Srebf1, Scd1, Scd2, Fas, Pnpla3, Acss2, Elovl5, Gpam, and Mylip (n = 10). Mann–Whitney U-test, ^∗P < 0.05, ^∗∗P < 0.01 compared with high-fat-fed ApoE^-^/^- mice. (B) Representative bands of hepatic TTC39B, LXRα, LXRβ, precursor, and mature SREBP-1 protein expression (n = 3). (C) Quantitative analysis of hepatic TTC39B, LXRα, LXRβ, precursor, and mature SREBP-1 protein levels (n = 3). ^∗P < 0.05, ^∗∗P < 0.01 compared with high-fat-fed ApoE^-^/^- mice. See Supplementary Figure S1 for original images.