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. 2018 Mar 9;5:25. doi: 10.3389/fmed.2018.00025

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Copyright © 2018 Nico, Conde, Rivera-Correa, Vasconcelos-dos-Santos, Mesentier-Louro, Freire-de-Lima, Arruda, Freire-de-Lima, Ferreira, Lopes Moreira, Zin, Vasconcelos, Otero, Palatnik-de-Sousa, Tanuri, Todeschini, Savino, Rodriguez and Morrot.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased levels of IgG4 autoantibody against to GD3 ganglioside in Zika virus infection during pregnancy. ELISA plates coated with GD3 ganglioside (20 µg/ml) were incubated with 1:100 dilution of sera from pregnant patients with Zika infection or control healthy pregnant individuals. The sera was obtained after pregnancy, and the reaction was developed with (A) anti-total IgG or (B) anti-Ig-specific subclasses conjugated to HRP. Scatter plots show individual values for each Zika-infected patient (n = 12) and healthy individual (n = 8). Means of data points for each individual ± SE are shown. Differences between groups are significant *(p ≤ 0.05).