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. 2018 Mar 15;8:4630. doi: 10.1038/s41598-018-22879-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TAF1 contains an evolutionarily conserved zinc knuckle. (A) Linear schematic of full length human TAF1 with percent conservation in eukaryotes shown. (B) Annotated TAF1 zinc knuckle conservation alignment spanning vertebrates, insects, nematodes, plants, and fungi. Zinc knuckle cysteines and histidine are boxed in blue. Conserved positive residues indicated by the green dots. (C) Sequence alignment of zinc knuckle containing proteins from eukaryotes and viruses. (D) Alignment of TAF1 ZnK model (blue) from I-TASSER prediction analysis with known structure of ZnK of HIV-1 nucleocapsid protein (green) and lin28 (purple); (E) Electrostatic surface map of HIV-1 nucleocapsid protein nucleic acid binding surface (right) and corresponding region of TAF1 ZnK (left).