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. 2018 Mar 15;8:4571. doi: 10.1038/s41598-018-23016-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effects on ChTX sensitivity of BK channel by β4 subunit mutants. (a) The time courses of blockade of mSlo1, mSlo1/β4, mSlo1/β4(G63A), mSlo1/β4(H105A), mSlo1/β4(N123A), mSlo1/β4(H153A) and mSlo1/β4(D166R) channels by ChTX. Each patch was perfused with 1 μM ChTX as indicated by the horizontal bars. (b) The blockades by 1 μM ChTX were plotted for mSlo1, mSlo1/β4, mSlo1/β4(G63A), mSlo1/β4(H105A), mSlo1/β4(N123A), mSlo1/β4(H153A) and mSlo1/β4(D166R) channels. (c) The blockades by 1 μM ChTX were plotted from Slo1/β4(H101Y) and other mSlo1/β4 mutant channels (groups 1 and 2 mutations at Asn123) described in the text.