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. 2018 Mar 15;8:4653. doi: 10.1038/s41598-018-22875-9

Figure 6.

Figure 6

Compound 12a has a high in vitro genetic barrier to drug resistance as shown by the serial viral pasage experiment. (A) Cartoon representation of the serial viral passage experiment. (B) Comparison of the in vitro genetic barrier of drug resistance between oseltamivir carboxylate and compound 12a.