Table 3.
Broad-spectrum antiviral activity and cytotoxicity of compound 12a.
| Influenza viruses | Drug sensitivity | EC50 (µM)a | MDCK CC50 (µM)a | A549 CC50 (µM)a | SIb |
|---|---|---|---|---|---|
| A/WSN/33 (H1N1) | 0.7 ± 0.1 | >214.3/140.1 | |||
| A/California/07/2009 (H1N1) | Amantadine resistant | 1.3 ± 0.4 | >115.4/75.5 | ||
| A/Denmark/524/2009 (H1N1) | Oseltamivir sensitive | 0.8 ± 0.2 | >187.5/122.6 | ||
| A/Switzerland/9715293/2013 (H3N2) | 1.4 ± 0.6 | >107.1/70.1 | |||
| A/Texas/04/2009 (H1N1) | 1.1 ± 0.4 | >136.4/89.2 | |||
| A/Denmark/528/2009 (H1N1) | Amantadine resistant Oseltamivir resistant | 0.9 ± 0.3 | >166.7/109.0 | ||
| A/Washington/29/2009 (H1N1) | 0.9 ± 0.3 | >150 | 98.1 ± 2.5 | >166.7/109.0 | |
| B/Wisconsin/1/2010 (Yamagata) | 0.8 ± 0.3 | >187.5/122.6 | |||
| B/Memphis/20/1996 (Yamagata) | 2.7 ± 0.2 | >55.6/36.3 | |||
| B/Utah/09/2014 (Yamagata) | Amantadine resistant Oseltamivir sensitive | 1.5 ± 0.3 | >100/65.4 | ||
| B/Phuket/3073/2013 (Yamagata) | 1.2 ± 0.2 | >125/81.8 | |||
| B/Brisbane/60/2008 (Victoria) | 0.6 ± 0.3 | >250/163.5 |
aThe values are the mean ± S.D. from two independent experiments. bSelectivity index is expressed as MDCK/A549.