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. 2017 Sep 19;43(2):251–257. doi: 10.1007/s13318-017-0437-7

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Mean (± SD) total and unbound (free) plasma concentration–time curves of the five probe drugs. The dashed line with open triangles represents the mean total plasma concentration–time curve after the control intervention. The solid line with closed triangles represents the mean total plasma concentration–time curve after the short-term fasting intervention. The dashed line with open circles represents the mean unbound plasma concentration–time curve after the control intervention. The solid line with open circles represents the mean unbound plasma concentration–time curve after the short-term fasting intervention