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. 2017 Nov 8;43(5):1119–1127. doi: 10.1038/npp.2017.229

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Individuals with major depressive disorder (MDD) exhibited altered gray matter volume and covariance. (a) Individuals with MDD exhibited increased volume in the right middle and inferior temporal gyri and reduced volume in the dorsal anterior cingulate (dACC) compared to healthy comparison (HC) participants. When these clusters were used as seeds for anatomical covariance analysis, individuals with MDD compared to HC participants exhibited significantly (p<0.05, corrected) (b) increased covariance between the middle/inferior temporal gyri and the orbital frontal cortex (OFC), and (c) decreased covariance between the dACC and the vermis in the anterior lobe of the cerebellum.