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. 2017 Nov 8;43(5):1119–1127. doi: 10.1038/npp.2017.229

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Copyright © 2018 The Author(s)

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Individuals with MDD showed altered connectivity for the vmPFC region detected from the ICD analysis (Figure 2c) to other regions of the PFC. (a) For HC participants, the vmPFC was significantly (p<0.05 corrected) correlated with regions of the default mode network (DMN) and negatively correlated with regions of the frontoparietal network (FPN), visual network, and the salience network (SAN). (b) For individuals with MDD, the vmPFC was significantly (p<0.05 corrected) connected to similar networks albeit at reduced strength. (c) For MDD compared to HC, seed connectivity revealed significantly increased (or significantly less negative) connectivity between the vmPFC and ventral lateral PFC and significantly reduced connectivity between the vmPFC and anterior prefrontal cortex.