Table 2. Brain Areas with Significant Causal Network Interaction with the Right and Left pACC across the Whole Sample of Obsessive-Compulsive Disorder and Healthy Control Participants (n=74; FDR corrected, q=10⁻⁵).

Brain regions	(Brodmann areas)	Cluster size	MNI coordinates
			X	Y	Z
The right pACC causal outflow to brain (n=74)
Right dorsomedial prefrontal cortex	10	26	2	60	1
Right thalamus		40	4	−10	6
Right supplementary motor area	6	55	4	8	66
Right precuneus	7	21	7	−55	57
The right pACC causal inflow from brain (n=74)
Right dorsal anterior midcingulate/presupplementary motor cortex	32/6	71	6	17	42
Right caudate		10	8	6	−4
Right thalamus		33	8	−12	3
Right precuneus	31	12	6	−54	22
Right anterior insula/lateral prefrontal cortex	23/47	22	38	16	−12
The left pACC causal outflow to brain (n=74)
Left thalamus		59	−3	−12	8
Left supplementary motor area		44	2	−4	72
Left precuneus	9	9	1	−46	60
The left pACC causal inflow from brain (n=74)
Left thalamus		10	−4	−14	−2
Left supplementary motor area	6	12	−2	8	54
Left precuneus	31	101	−8	−56	30
Left middle frontal gyrus	8	45	−22	32	44
Left postcentral	3	20	−24	−32	76

Abbreviations: BA, Brodmann area; pACC, pregenual anterior cingulate cortex; MNI, Montreal Neurological Institute.