Figure 3.

Correlation between IFGO mean activation and peripheral mean FKBP5 methylation in MDD. Lower peripheral DNA methylation of FKBP5 intron 7 was associated to a higher activation in ERT>SRT in patients (Wald chi-square=5.58, p=0.02). Activation values are adjusted for site, age, sex, medication, rs1360780, valence and side (residuals) and a least-squares fit line is shown. IFGO, inferior frontal gyrus pars orbitalis; ERT, emotional recognition trials; SRT, shape recognition trials; MDD, major depressive disorder patients.