Fig. 1.

HHcy aggravated glucose intolerance and reduced body weight of db/db mice. A. Body weight. B. Total plasma homocysteine (tHcy) levels. C. Blood glucose levels. D. Oral glucose tolerance test (OGTT). E. 24 h water intake. F. 24 h urine excretion. At the age of 8-week, db/+ and db/db mice were fed with a high methionine diet (HM, methionine: 2% w/w) for 8 weeks. db/+ and db/db mice fed with a control diet (CT, methionine: 0.37% w/w) served as controls. n = 5–10, * p < 0.05 vs db/+ mice on CT diet (db/+_CT); †p < 0.05 vs db/+ mice on HM diet; ‡p < 0.05 vs db/db mice on CT diet (db/db_CT). HHcy, hyperhomocysteinemia.