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Dose effects of RTD-1 on airway cytokines and chemokines. To assess the dose response of RTD-1, mice received pretreatment with 0, 0.2, 1, 5, or 25 mg/kg RTD-1 0.5 hour before 1-μg intranasal LPS instillation. BAL fluid was obtained at 24 hours. Effect of RTD-1 on cytokines (A) IL-1β, (B) TNF, and (C) IL-6 are shown; n = 6 mice per group; geometric mean (±95% CI). Treatment compared with control by one-way ANOVA with the Bonferroni post test *P < 0.05, **P < 0.01, ***P < 0.001.
