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. 2017 Dec 29;118(5):2491–2553. doi: 10.1021/acs.chemrev.7b00373

Figure 59.

Figure 59

(a) Cofactor arrangement in a cytochrome c oxidase (PDB: 2YEV) and the structure of binuclear heme a3/CuB center (BNC). (b) General catalytic cycle of CcO and important intermediates involved (R, A, PM, F, O, and E). This mechanism is produced according to the catalytic cycles shown in refs (561) and (562).