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. 2018 Mar 15;197(6):776–787. doi: 10.1164/rccm.201707-1371OC

Figure 6.

Figure 6.

Effects of postnatal intraperitoneal (i.p.) monoclonal antibody (mAb) therapy after intraamniotic (i.a.) sFlt-1 (soluble fms-like tyrosine kinase 1) exposure. (A–C) In comparison with lungs from untreated rats that were exposed to i.a. sFlt-1, postnatal mAb therapy improved lung histology and increased radial alveolar counts (A), increased vessel density (B), and improved the development of right ventricular hypertrophy (C). Postnatal treatment with nonspecific IgG had no effect on lung structure or right ventricular hypertrophy. Scale bars: (A) 100 μm; (B) 250 μm. Error bars show SEM. Numbers of pups studied in each group are: control (CTL), n = 20; sFlt-1, n = 12; sFlt-1 + IgG, n = 11; sFlt-1 + mAb (1 mg/kg), n = 12; sFlt-1 + mAb (10 mg/kg), n = 12. HPF = high-power field; LV = left ventricle; RV = right ventricle; S = septum.