. Author manuscript; available in PMC: 2018 Mar 16.

Published in final edited form as: Handb Exp Pharmacol. 2017;240:71–101. doi: 10.1007/164_2016_39

Table 1.

Mitochondria ion channels, their localization, selectivity, and conductance

Name	Location	Selectivity	References
VDAC1	OMM	Cl selective at the open state of channel [P_Ca = 0.94 ± 0.05, P_Cl = 22.6 ±0.2(×10⁻¹⁶ L/s)], also permeable to calcium at the closed state [P_Ca = 4 ±1, P_Cl = 5 ±1(×10⁻¹⁶ L/s)], conductance of 2.4–4.3 nS at Vm = 10 mV	Szabo and Zoratti (2014), Tan and Colombini (1768), and De Pinto et al. (1987)
VDAC2	OMM	Cl selective, conductance varied as it showed lower conductance (1.55 ±0.01 nS at 5 mV) and higher conductance (1.71 ±0.01 nS at 12 mV). On an average conductance reported were 3.79 ±0.10 nS.	Xu et al. (1999) and Menzel et al. (2009)
VDAC3	OMM	Cl selective at a holding potential of 12 mV, a small conductance of 0.68 nS–0.71 nS at tenfold KCl gradient	Checchetto et al. (2014), Colombini (2004), and Xu et al. (1999)
CLIC4	OMM	15 pS (500/50 mM KCl), 30 pS (140 mM KCl), 1 pS (300:140 mM choline Cl), 43 (50 mM choline chloride)	Ponnalagu et al. (2016a), Duncan et al. (1997), Ponnalagu et al. (2016b), Singh and Ashley (2007), and Proutski et al. (2002)
IMAC	IMM	P_Cl/P_K is 4.5, 107–110 pS in symmetrical 150 mM KCl.	Sorgato et al. (1987), Klitsch and Siemen (1991), and Sorgato et al. (1989)
CLIC5	IMM	Varied from ~3–116 pS (500/50 mM KCl) when reconstituted in planar bilayers, 26 pS, 100 pS and 400 pS (140 mM KCl), 100/280 pS (140 mM), 42 pS (140 mM KCl)	Ponnalagu et al. (2016a), Ponnalagu et al. (2016b), Singh et al. (2007), Landry et al. (1989), Weber-Schurholz et al. (1993), and Edwards et al. (1998)
mPTP	IMM	0.9–1.5 nS (150 mM KCl), average conductance of ~1.3 nS in patch clamp studies, low anion selectivity, and sometimes exhibit cation selectivity	Szabo and Zoratti (2014), De Marchi et al. (2006), and Petronilli et al. (1989)
Maxi Cl channel	IMM	400 pS (fourfold KCl gradient) in patch clamp studies under reversal potentials of −26 to −31, P_Cl/P_K ≈ 7 to 18	De Marchi et al. (1777)
UCP	IMM	~75 pS at positive holding potential (symmetrical 100 mM KCl) in patch clamp studies. ~84 pS at negative holding potential, inward rectifying Cl⁻ currents were observed.	Huang and Klingenberg (1996)