Figure 1.

Cell-cycle synchronization data by Spellman et al. (12). The data set composed of 800 cell-cycle-associated genes has been projected by CA as is. No HMS has been used so as not to bias the resulting plot in terms of separation of the cell-cycle phases. The outlying hybridizations have been identified to be caused by a slight phase shift of the cdc15-based synchronization visible in b Upper Right, which shows the profiles of the nine histone genes HHF1, HHF2, HHT1, HTB2, HHT2, HTB1, HTA1, HTA2, and HHO1, encircled in black in a. Additional explanation is given in the text.