Table 1.

Schedule of visits and assessments

Visit	0	1	2	3	4	5	6	7	8	9
	Screening	Baseline
Week		0	2	3	4	8	12	16	20	24
Study medication period (24 weeks)
Screening and consent
Assessment of current medication	x	x	x	x	x	x	x	x	x	x
Informed consent	x
Ongoing capacity	x	x	x	x	x	x	x	x	x	x
Inclusion/exclusion criteria	x
Beta-HCG (females only)	x
Drug dispensation (after randomisation)		x	x	x	x	x	x	x	x	x
Safety
Adverse events			x	x	x	x	x	x	x	x
SAFTEE-SI		x	x	x	x	x	x	x	x	x
Vitamin B12		x					x			x
Efficacy
Height	x	x
Body weight	x	x	x	x	x	x	x	x	x	x
Waist circumference and hip/waist ratio		x	x	x	x	x	x	x	x	x
Blood pressure		x	x	x	x	x	x	x	x	x
Fasting glucose, insulin		x					x			x
Fasting cholesterol, HDL, LDL, triglycerides		x					x			x
Haemoglobin A1c		x					x			x
OGTT		x								x
Other
Heart rate		x	x	x	x	x	x	x	x	x
PANSS		x					x			x
GAF		x					x			x
SIMPAQ/IPAQ		x					x			x
AQOL		x					x			x
TOPF		x								x
CVLT-II short form		x								x
Symbol Digit Modalities Test		x								x
Controlled Oral Word Association Test		x								x
Trail Making Test		x								x
Food Craving Inventory		x					x			x
Other
Drug compliance			x	x	x	x	x	x	x	x
Blood (other)—FBC (including WCC, neutrophils), ELFT (including serum bicarbonate and lactate) clozapine/nor clozapine levels		x					x			x

AQoL, Assessment of Quality of Life; CVLT-II, The California Verbal Learning Test second edition; ELFT, Electrolytes and Liver Function Tests; FBC, full blood count; GAF, Global Assessment of Functioning; HCG, human chorionic gonadotropin; HDL, high-density lipoprotein; IPAQ, International Physical Activity Questionnaire; LDL, low-density lipoprotein; OGTT, Oral Glucose Tolerance Test; PANSS, Positive and Negative Syndrome Scale; SAFTEE-SI, Systematic Assessment for Treatment Emergent Events-Systematic Inquiry; SIMPAQ, Simple Physical Activity Questionnaire; TOPF, Test of Premorbid Functioning.