Table 2.
Overview over inventories and data collection tools used in the different studies and the age of assessment
| Outcomes to be measured | Bangalore | Delhi | Dar es Salaam | |
| Vitamin B12 exposure | Pregnancy | Child | Pregnancy | Child |
| Outcomes to be measured | Age (year) | Age (year) | Age (year) | Age (year) |
| General abilities | ||||
| Modified KABC-II* EACABT | 5, 6 | 11–15 | 7–10 | |
| WISC-IVINDIA | 7–9 | |||
| Verbal abilities | ||||
| Crichton Vocabulary Scale, Hindi edition | 7–9 | |||
| Neurophysiological tests | ||||
| Event-related potential† | 6 | |||
| Neuropsychological tests | ||||
| NEPSY-II | 7–9 | |||
| Questionnaires | ||||
| Brief‡ | 5.5 | 7–9 | 11–15 | 7–10 |
| SDQ | 6.5 | 7–9 | 11–15 | 7–10 |
| VSMS | 5 | |||
| Maternal assessment | ||||
| Demography | 5 | 7–9 | 11–15 | 7–10 |
| Anthropometry | 5, 5.5, 6, 6.5 | 11–15 | 7–10 | |
| Home environment | 5.5 | 11–15 | 7–10 | |
| Nutrition | ||||
| 24-hour diet recall form | 5, 5.5, 6, 6.5 | 7–9 | ||
| Anthropometry | 5, 5.5, 6, 6.5 | 7–9 | 11–15 | 7–10 |
| Household food security questionnaire | 5, 6 | |||
| Medical morbidity | ||||
| Morbidity questionnaire | 5, 5.5, 6, 6.5 | 11–15 | 7–10 | |
| Biomarkers | ||||
| Vitamin B12 | 5, 6 | 7–9 | 6–24 m§ | |
| CBC, MMA, HcY, RBC folate, CRP | 5, 6 | 7–9 | ||
| Haemoglobin | 5, 6 | 7–9 | 11–15 | 7–10 |
*In Bangalore: Atlantis, number recall, word order, pattern reasoning and triangles from KABC and Koh’s Block Design Test and Verbal Fluency in addition; in Dar es Salaam: the EACABT with permission from Savings Brain Multisite Study (WHO/BMGF) including Atlantis, hand movements, footsteps, story completion, Kilifi Naming Test, ROCF, NOGO, shift, people search, literacy and numeracy, HOME, Brief-P (modified from MAL-ED), SDQ, BQP, in addition to verbal fluency and Koh’s Block.
†ENOBIO 32 (Device name)—brain monitoring and stimulation technologies, mismatch negativity, P300 (Neuroelectrics, Boston, MA).
‡Different versions used in different sites: in Bangalore: Brief Parent; in Delhi: Brief Second Edition; in Dares es Salaam: Saving Brains/Gates/WHO modified version from the malaria study.
§On stored serum samples from Child II cohort (subject to funding).
BMGF, Bill & Melinda Gates Foundation; BQP, Behavior Questionnaire for Parents; CBC, complete blood count; CRP, C reactive protein; EACBT, African Cognitive Assessment Battery; HcY, homocysteine; HOME, Home Observation Measurement of the Environment; KABC, Kaufman Assessment Battery for Children; MAL-ED, Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development, MMA, methylmalonic acid; NEPSY-II, A Developmental NEuroPSYchological Assessment; NOGO, go/no go test for sustained attention and response control; RBC folate, red blood cell folate analysis; ROCF, Rey–Osterrieth complex figure; SDQ, Strengths and Difficulties Questionnaire; VSMS, Vineland Social Maturity Scale; WISC-IVINDIA, Wechsler Intelligence Scale for Children VI, Indian version.