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. 2001 Sep 4;98(19):10805–10810. doi: 10.1073/pnas.191567898

Figure 4.

Figure 4

Phosphorylation of c-jun and p38 MAPK is CD28-independent in DO11.10 T cells. Mice were transferred with either naïve DO11.10 (squares) or CD28-deficient (circles) DO11.10 T cells. Phosphorylation of c-jun (A) or p38 MAPK (D) was assessed at the indicated times after i.v. injection of ovalbumin peptide. The difference between the signal (mean fluorescence intensity, MFI) in DO11.10 and recipient CD4 T cells is shown. C shows histograms of phospho-p38 MAPK staining in DO11.10 (bold line) or recipient (thin line) CD4 T cells at the indicated times after i.v. injection of ovalbumin peptide. Intracellular IL-2 was measured 2.5 h after i.v. injection of ovalbumin peptide (closed bars) or nothing (open bars) (B). These data are representative of two independent experiments.