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. 2018 Apr;25(4):147–157. doi: 10.1101/lm.046391.117

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© 2018 Huang et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Learning & Memory, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — The pairing of α₂-AR activation and 10-Hz stimulation induced LTP. (A) Records showing NA-facilitated LTP. Ten trains of 10-Hz stimulation elicited the short-term potentiation of transmission that decayed back to baseline (Control). However, pairing this stimulation with a perfusion of NA (10 µM) resulted in the generation of robust LTP. AP5 (50 µM) blocked NA-facilitated LTP as well. Note that NA reduced the baseline fEPSP slope during test stimulation and enhanced it immediately after the drug washed out. (B) Phentolamine (Phe), but not propranolol (Pro), blocked the NA effect. (C) Blockade of the NA effect was also obtained by idazoxan (Ida) but not by prazosin (Pra). (D) The NA effect was mimicked by clonidine (Clo). The bars indicate drug application. (E) The effects of the AR agonists and antagonists. (***) P < 0.001 versus the no-drug control (Cont), ANOVA (F_(6,43) = 10.99, P < 0.001) followed by Dunnett's test.